Description
The inhibitory effect of anti-thrombin III (AT-III) on thrombin, factor IIa and other coagulation serine proteases in plasma is increased several thousand-fold by enoxaparin. This inhibition accounts for the anticoagulant effect of enoxaparin. The quantitative determination of enoxaparin levels by the measurement of their anti-IIa activity is a necessary tool for monitoring treatment efficacy. Presence of Enoxaparin catalyzes the reaction between AT lll and _-Thrombin. The factor IIa inhibition test is the most useful assay covering the widest variety of enoxaparin preparations. In the assay, the rate of factor IIa inhibition is directly proportional to the enoxaparin concentration since both factor IIa and AT-III are in excess. The residual factor IIa activity is inversely proportional to the enoxaparin concentration.
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