TNF-Alpha inhibitors in inflammatory diseases: A Brief Review Introduction: Tumor Necrosis Factor-alpha (TNF-alpha) is a biologically active protein that exists as a 26 kDa membrane-bound precursor (mTNF-α). Upon cleavage by TNF-α converting enzyme (TACE), it is released as a soluble 17 kDa protein. These proteins bind to the widely expressed TNF-α receptors 1 and 2, […]
