Host Cell DNA Contamination Assays

Host Cell DNA ELISA is a critical analytical technique for biopharmaceutical and vaccine research and manufacturing. Cell lines used as expression systems inadvertently produce host cell DNA contaminants that can impact safety, efficacy, and quality of the final product. Although low levels of most contaminants may be inconsequential, patient safety importance requires that they be eliminated or reduced to the lowest levels to avoid problems such as adverse immune reactions.

To ensure the safety of recombinant-expressed biopharmaceuticals as well as vaccines, health authorities are demanding the close monitoring of HCP DNA impurities by applying host cell DNA detection methods with high sensitivity and specificity.

Krishgen’s range of sensitive Host cell DNA ELISA allow for accurate detection of these bioprocess contaminants. A brief list of ELISA includes kits for various host cell systems, designed to meet the diverse needs of biopharmaceutical researchers and manufacturers. Our focus is on ensuring low intra-assay variability that allows for streamlined testing across production batches. Detect and quantify Host cell DNA concentrations at any point in your purification processes.