Description
Background:
Dostarlimab, sold under the brand name Jemperli, is a monoclonal antibody used as an anti-cancer medication for the treatment of endometrial cancer. Dostarlimab is a PD-1 blocking immune checkpoint inhibitor monoclonal antibody. Dostarlimab was approved for the treatment of endometrial cancer in both the United States and the European Union in April 2021
Intended Use:
For Estimation of Dostarlimab in human serum and plasma. Please note the kit has not been optimized to be used for any other animal species. Should you require a specific sera tested, please connect with us at sales@krishgen.com for optimization.
Principle:
The method employs the quantitative sandwich enzyme immunoassay technique. Antibodies to Dostarlimab are pre-coated onto microwells. Samples and standards are pipetted into microwells and human Dostarlimab present in the sample are bound by the capture antibody. Then, a HRP (horseradish peroxidase) conjugated anti-Dostarlimab antibody is pipetted and incubated. After washing microwells in order to remove any non-specific binding, the ready to use substrate solution (TMB) is added to microwells and color develops proportionally to the amount of Dostarlimab in the sample. Color development is then stopped by addition of stop solution. Absorbance is measured at 450 nm.
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