Description
Background:
Lulizumab pegol is an ADC with an auristatin toxophore linked to a humanized monoclonal antibody targeting C4.4A via a noncleavable alkyl hydrazide linker. C4.4A, a structural homologue of the urokinase receptor, is a cell surface protein highly expressed in NSCLC, especially lung squamous cell carcinoma. In vitro experiments have shown that lupartumab amadotin effectively inhibited tumor cell proliferation in C4.4A-expressing lung cancer cells. It is under investigation in clinical trial NCT02843659 (Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjgren’s Syndrome).
Intended Use:
For Estimation of Lulizumab Pegol in human serum and plasma. Krishgen’s range of KRIBIOLISA kits are developed using the high quality raw materials and are thoroughly validated for accuracy and precison. They allow quantification of serum or plasma protein drug levels, and can be used for biosimilar and generics research to understand pharmacokinetic properties of the drug. Please note the kit has not been optimized to be used for any other animal species. Should you require a specific sera tested, please connect with us for optimisation.
If you have published a paper by using any of our ELISA since 01/01/2023, kindly fill out the “Krishgen Publication Reward Application Form” with complete information and send it by at email: info@krishgen.com, with the subject “Krishgen Publication Reward”. We will get back to you with the Amazon / Krishgen Credit Reward after we confirm it ASAP!