Description
Background:
Neurofilament-light chain (NFL) is a structural protein predominantly expressed in neurons, particularly in axons. Elevated levels of NFL in cerebrospinal fluid (CSF) and blood are indicative of neuronal damage and axonal degeneration, making it a promising biomarker for various neurological conditions, including neurodegenerative diseases, traumatic brain injury (TBI), and multiple sclerosis (MS). The Human NFL ELISA Kit provides a reliable method for measuring NFL concentrations in human serum, plasma, and CSF samples, facilitating studies aimed at understanding neuronal injury, disease progression, and therapeutic interventions.
Pathways and Relevance:
The Human NFL ELISA Kit is instrumental in elucidating pathways associated with neuronal damage, axonal degeneration, and neuroinflammation in neurological disorders. By quantifying NFL levels, researchers can assess disease severity, monitor disease progression, and evaluate treatment responses. Furthermore, NFL serves as a prognostic marker for neurological outcomes and disease progression, highlighting its relevance in clinical practice and translational research. Ongoing research endeavors include investigating the mechanisms underlying NFL release, identifying biomarkers for early detection of neurological dysfunction, and developing targeted therapies to preserve neuronal integrity and mitigate disease progression. Additionally, researchers are exploring the potential of NFL as a non-invasive biomarker for assessing treatment responses and predicting clinical outcomes in patients with neurological disorders, driving innovation and shaping the future of neurology and neurodegenerative disease research.
Validated against seven points for a “GOLD RING” Standard Quality ELISA – the benchmark sign for Krishgen Quality. The The GENLISA ELISA kits are used for assessing the specific biomarker in samples analytes which may be human serum, plasma, biological fluids and cell culture supernatant. The kit uses indirect sandwich assay with double antibodies – capture and detection to ensure a high degree of sensitivity and specificity in the estimation of Neurofilament-Light Chain (NFL);
If you have published a paper by using any of our ELISA since 01/01/2023, kindly fill out the “Krishgen Publication Reward Application Form” with complete information and send it by at email: kbiinfo@krishgen.com, with the subject “Krishgen Publication Reward”. We will get back to you with the Amazon / Krishgen Credit Reward after we confirm it ASAP!