KRIBIOLISA Neutralizing Antibodies to Natalizumab (Tysbari) ELISA includes features like:
– Ready to use protocol with break-apart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a ?GOLD RING? Standard Quality ELISA – the benchmark sign for Krishgen Quality. KRIBIOLISA ELISA kit is used for assessing the specific biomarker in samples analytes which may be human serum, plasma, biological fluids and cell culture supernatant. The kit uses indirect sandwich assay with double antibodies / recombinant proteins – capture and detection to ensure a high degree of sensitivity and specificity in the estimation of the analyte. Extensive validation has been done on these kits. Please ask for our validation guide if not availableon our product page. Incase you wish us to customize the kit, connect with us at sales1@krishgen.com
Background: All NAbs are binding anti-drug antibodies (ADA), but not all ADA are neutralizing. NAbs reduce or block a therapeutic?s biological activity?by preventing target binding, receptor activation, enzyme activity, or cellular uptake (for ERTs/ADCs).
Surrogate/competitive ELISA for neutralization (most kit-friendly) from KRISHGEN measures inhibition of drug?target (or drug?receptor/ligand) binding. The Kit is stable, fast, and is capable of high throughput; where no cells are required. The kits align best when the mechanism is binding-driven.