Pseudo UTP Solution substitutes UTP during IVT reactions to produce pseudouridine-modified RNA.
Enhances RNA stability and translation efficiency. It also helps reduce innate immune activation in therapeutic mRNA (e.g., vaccines, gene therapy). This solution is commonly used with Cap analogs (CleanCap) and modified nucleotides (m5C, m1?).
The key advantages of Pseudo UTP solution is that it mimics uridine structurally but improves biological stability of RNA. It also helps reduce immunogenicity compared to unmodified UTP and is widely used in mRNA therapeutics, CRISPR guide RNA synthesis, and RNA vaccines.