Semaglutide: An Overview Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has gained considerable attention in the past couple of years due to its potential applications in both the treatment of diabetes and weight loss/metabolism. With US FDA and EMA approvals in place (Ozempic and others) and related GLP-1 agonist analogs being developed, it is crucial […]
CHO Cells How Chinese Hamster Ovary Cells are the Unwavering Champion of Biologics Production The biopharmaceutical industry is witnessing remarkable growth with the development of innovative protein-based therapies. Behind this revolution stands a silent yet powerful champion: Chinese Hamster Ovary (CHO) cells. These cells have become the gold standard in biopharmaceutical production, playing a vital […]
Technical Note: Neutrophils and their Markers Neutrophils form the first line of defense against invading pathogens. These abundant granulocytes, constituting 50-70% of circulating white blood cells, are the body’s rapid responders, armed with potent antimicrobial weaponry and an impressive arsenal of cell surface markers. A part of the polymorphonuclear cells family (PMNs) together with basophils and eosinophils, they are formed […]
TNF-Alpha inhibitors in inflammatory diseases: A Brief Review Introduction: Tumor Necrosis Factor-alpha (TNF-alpha) is a biologically active protein that exists as a 26 kDa membrane-bound precursor (mTNF-α). Upon cleavage by TNF-α converting enzyme (TACE), it is released as a soluble 17 kDa protein. These proteins bind to the widely expressed TNF-α receptors 1 and 2, […]
Causes Of High Background In ELISA Tests and How to Solve Them ELISA tests are widely used in medical diagnostics, research, and Drug Development and various fields of biology. However, since they are often run manually, there are chances of human error that may cause high background and therefore incorrect results and quantification of analyte. […]
BiTE Antibodies: A Promising Cancer Therapy About Bispecific Antibodies A bispecific antibody drug (BsMAb, BsAb) is a synthetic protein that can bind to two distinct antigen types or two distinct epitopes on the same antigen at the same time. BsAbs can be produced in a variety of structural forms and can be created to induce […]
How To: Correctly Reconstitute Lyophilised Reagents How To Correctly Reconstitute Lyophilized Reagents for Use in ELISA Lyophilized reagents are a common form of storage for various substances in research labs. Most of Krishgen’s KRIBIOLISA immunoassays and several GENLISA assays come with lyophilised standards for better stability. Whether you’re an experienced research scientist or just starting […]
ELISA Sample Preparation FAQs Krishgen’s ELISA are available under two product types: GENLISATM branded products are ELISA for cytokine and biomarker testing in various species including humans, rat, mouse and other species. These ELISA have been validated for use with serum, plasma and cell culture supernatant samples. KRIBIOLISATM branded products are specialised for biopharma related […]
Top 15 Apps for Researchers We know that academic researchers and PhD scientists are always on the lookout for tools and resources that can help them be more productive and efficient in their work. There now exist a plethora of apps for various tasks available that can help make work easier and more streamlined. Krishgen’s […]
Artificial Intelligence in Drug Discovery Research: A Brief Overview Artificial intelligence, as it evolves, has become an increasingly important tool in life sciences research in recent years. The ability of machine learning algorithms to analyse large amounts of data quickly and accurately has made it possible for scientists to identify new patterns and insights in […]
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