The development of alternative, patient-friendly drug delivery routes for peptide-based therapeutics continues to be a major focus in pharmaceutical research. At the Drug Delivery to the Lungs (DDL) Conference 2025, a peer-reviewed study presented by Glieca et al. explored an innovative approach to delivering semaglutide, a widely used GLP-1 receptor agonist, via the pulmonary route. […]
Krishgen BioSystems 2026 Calendar Theme Scientific progress is never sudden – it is cumulative. Every modern method, every assay, every therapeutic innovation, and every research workflow we rely on today has been shaped by decades of foundational discoveries. As an Indian manufacturer serving the global life sciences community, Krishgen BioSystems believes India’s scientific story deserves […]
The development and production of biotherapeutics, including monoclonal antibodies, recombinant proteins, and gene therapy vectors, require rigorous control of process- and product-related impurities. These impurities can influence the safety, efficacy, and stability of the final therapeutic product. As regulatory agencies increasingly emphasize the importance of critical quality attributes (CQAs), enzyme-linked immunosorbent assays (ELISAs) have emerged […]
Popular Targets for Bispecific Antibody Drugs Bispecific Antibody drugs have gained considerable popularity since the approval of blinatumomab. Currently, six bsAb drugs have been approved by the US FDA / EMA and over 180 are currently in clinical trials. BsAb simultaneously recognize different antigens or epitopes, resulting in a diverse range of therapeutic mechanisms. With a […]
Semaglutide: An Overview Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has gained considerable attention in the past couple of years due to its potential applications in both the treatment of diabetes and weight loss/metabolism. With US FDA and EMA approvals in place (Ozempic and others) and related GLP-1 agonist analogs being developed, it is crucial […]
CHO Cells How Chinese Hamster Ovary Cells are the Unwavering Champion of Biologics Production The biopharmaceutical industry is witnessing remarkable growth with the development of innovative protein-based therapies. Behind this revolution stands a silent yet powerful champion: Chinese Hamster Ovary (CHO) cells. These cells have become the gold standard in biopharmaceutical production, playing a vital […]
Technical Note: Neutrophils and their Markers Neutrophils form the first line of defense against invading pathogens. These abundant granulocytes, constituting 50-70% of circulating white blood cells, are the body’s rapid responders, armed with potent antimicrobial weaponry and an impressive arsenal of cell surface markers. A part of the polymorphonuclear cells family (PMNs) together with basophils and eosinophils, they are formed […]
TNF-Alpha inhibitors in inflammatory diseases: A Brief Review Introduction: Tumor Necrosis Factor-alpha (TNF-alpha) is a biologically active protein that exists as a 26 kDa membrane-bound precursor (mTNF-α). Upon cleavage by TNF-α converting enzyme (TACE), it is released as a soluble 17 kDa protein. These proteins bind to the widely expressed TNF-α receptors 1 and 2, […]
Causes Of High Background In ELISA Tests and How to Solve Them ELISA tests are widely used in medical diagnostics, research, and Drug Development and various fields of biology. However, since they are often run manually, there are chances of human error that may cause high background and therefore incorrect results and quantification of analyte. […]
BiTE Antibodies: A Promising Cancer Therapy About Bispecific Antibodies A bispecific antibody drug (BsMAb, BsAb) is a synthetic protein that can bind to two distinct antigen types or two distinct epitopes on the same antigen at the same time. BsAbs can be produced in a variety of structural forms and can be created to induce […]
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