Immunotherapy

Immunotherapy for Cancer

Immunotherapy for cancer has been one of the more effective treatments, long being researched upon. Several types of immunotherapy are used to treat cancer, including:

Immune checkpoint inhibitors, which are drugs that block immune checkpoints. These checkpoints are a normal part of the immune system and keep immune responses from being too strong. By blocking them, these drugs allow immune cells to respond more strongly to cancer.

Krishgen has a wide range of assays that are designed to quantify and study immune checkpoint inhibitors and stimulators. Find the product you need.

T-cell transfer therapy, which boosts the natural ability of T cells to fight cancer, includes tumour infiltrating lymphocytes (TIL), or the currently popular CAR-T cell therapy. T-cell transfer therapy may also be called adoptive cell therapy, adoptive immunotherapy, or immune cell therapy. Krishgen is already working on a wide range of assays for t-cell transfer therapy. If you require a specific assay, we can custom develop that for you as well.

Monoclonal antibodies, or therapeutic antibodies, designed to bind to specific targets on cancer cells, have become one of the most successful and important approved strategies for treating patients. Several different types of monoclonal antibody drugs and their biosimilars have been approved across the US (FDA) and EU (CE). mAbs may target and destroy a tumour cell directly, or through immune modulated mechanisms including CDC. Some may block and prevent the growth of the tumour as well.

Krishgen has a range of assays for the pharmacokinetic research and development of monoclonal antibody drug targets and therapies. You can find them here.

Treatment vaccines, different from preventative vaccines like the Ovarian cancer vaccine that has been approved, have the potential to stimulate specific immune responses against tissues. These, theoretically, protect normal tissues, and induce only tumour lysis.

Peptide vaccines, whole tumour cell vaccines and dendritic cell vaccines are three types of vaccine strategies being studied and researched. While none have yet shown much clinical efficacy, there are some potential candidates in the pipelines.

Immune system modulators, which enhance the body’s immune response against cancer. Some of these agents affect specific parts of the immune system, whereas others affect the immune system in a more general way. Learn more about immune checkpoints and our available research assays.

Immunotherapy for Autoimmune Diseases
Targeted immunotherapy for auto-immune diseases has been the focus of treatment research for some time now. Several proposed molecules are already undergoing clinical trials, including some anti-inflammatory trials and cytokine trials, however, there are not yet many that have shown complete efficacy.