Powered by Bioz
Angiotensin-converting enzyme 2 (ACE2)[5] is an enzyme that can be found either attached to the membrane of cells (mACE2) in the intestines, kidney, testis, gallbladder, and heart or in a soluble form (sACE2).Angiotensin-converting enzyme 2 (ACE2), discovered as a homologue of ACE, acts as its physiological counterbalance providing homeostatic regulation of circulating angiotensin II (Ang II) levels. ACE cleaves angiotensin I hormone into the vasoconstricting angiotensin II which causes a cascade of hormonal reactions which is part of the body’s harmful phase of RAAS, which ultimately leads to an increase in the body’s blood pressure. ACE2 has an opposing effect to ACE, degrading angiotensin II into angiotensin (1-7), thereby lowering blood pressureACE2 is a zinc metalloenzyme and carboxypeptidase located as an ectoenzyme on the surface of endothelial and other cells.
The GENLISA Human Angiotensin I Converting Enzyme 2 (ACE2) ELISA includes features like: – Ready to use protocol with break-apart wells for ease of use – Standardisation and High Reproducibility – Lot to Lot Consistency – Accuracy and Precision Validated against seven points for a GOLD RING Standard Quality ELISA – the benchmark sign for Krishgen Quality. The The GENLISA ELISA kits are used for assessing the specific biomarker in samples analytes which may be human serum, plasma, biological fluids and cell culture supernatant. The kit uses indirect sandwich assay with double antibodies – capture and detection to ensure a high degree of sensitivity and specificity in the estimation of Angiotensin I Converting Enzyme 2 (ACE2)
