Background: Interleukin 12 receptor beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1 (CD212) is a subunit of the interleukin 12 receptor. IL12RB1 (CD212) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds with low affinity to interleukin 12 (IL12) and is probably part of the IL12 receptor complex. IL12RB1 (CD212) forms a disulfide-linked oligomer that is required for its IL12-binding activity. Coexpression of IL12RB1 and IL12RB2 proteins has been shown to result in the formation of high-affinity IL12 binding sites and restoration of IL12-dependent signaling. Lack of expression of this gene has been found to cause immunodeficiency in patients with severe mycobacterial and salmonella infections. IL12RB1 (CD212) Acts as an interleukin receptor that binds interleukin-12 with low affinity and is involved in IL12 transduction. It binds to IL12RB2 and forms a functional high-affinity IL12 receptor. IL12RB1 (CD212) also associates with IL23R to form an interleukin-23 receptor that functions in IL23 signaling, probably through activation of the Jak-Stat signaling cascade.The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of IL-12RB1 pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.