Background: Interleukin-13 receptor alpha-2 subunit (IL13RA2/IL-13RA2) is also known as cluster of differentiation 213A2 (CD213A2), IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, and IL -13RA2. IL13RA2 is frequently overexpressed in brain tumors, making Il13ra2 one of the vaccine targets for glioma immunotherapy. IL13RA2/IL-13RA2 is a cancer-associated receptor present in more than 80% of high-grade astrocytomas (HGA) and recently identified as a cytokine that promotes breast cancer cell metastasis. IL13Ralpha2 expression was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to fetal bovine serum mediators in the environment. None of the malignant glioma cell lines cultured in vitro and tested so far expressed the IL13Ralpha2 receptor. Recombinant virus (R5111) enters cells through interaction with the IL13Ralpha2 receptor in a manner indistinguishable from the interaction of wild-type virus with its receptors.The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of IL-13RA2 pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.