Background: IL17, also known as IL17a, is a cytokine belonging to the IL-17 family. Cytokines are protein-rich signaling compounds that are the most important mediators of the immune response. They regulate many different cellular functions, including proliferation, differentiation, and cell survival/apoptosis, but are also involved in several pathophysiological processes, including viral infections and autoimmune diseases. Cytokines are synthesized by several cells of the innate (monocytes, macrophages, dendritic cells) and adaptive (T and B cells) immune system under the influence of various stimuli. The IL-17 cytokine family includes six members: IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by several types of cells IL-17 regulates the activity of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2) and improve nitric oxide (NO) production. High levels of IL-17 are associated with several chronic inflammatory diseases, including rheumatoid arthritis, psoriasis and multiple sclerosis..The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of IL-17A pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.