Background: IL23R, also known as the IL23 receptor, belongs to the type I cytokine receptor family, type 2 subfamily. It contains two type III fibronectin domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R binds to IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates stimulation of T cells, NK cells, and possibly some macrophages/myeloid cells, probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in the acute response of peripheral tissues to infection. IL23 can cause autoimmune inflammatory diseases and is important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic relapsing gastrointestinal inflammation with a complex etiology. Genetic variations in IL23R may also contribute to type 7 psoriasis..The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of IL-23R pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.