Background: Mucosal addressable cell adhesion molecule-1 (MAdCAM-1) plays a key role in endothelial adhesion and lymphocyte migration to inflammatory sites in inflammatory disease. In vitro and in vivo data show that inhibition of mucosal targeting of the cell adhesion molecule (MAdCAM) pathway reduces leukocyte arrival to the gut by blocking the interaction between MAdCAM and its ligand, the lymphocyte-expressed alpha4beta7 integrin.The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of MAdCAM-1 pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.