Background: OX40 (CD134) and its binding partner OX40L (CD252) are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily and can break existing tolerance to malignancy, leading to reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in the expansion and survival of antigen-specific T cells. OX40 and OX40L also regulate cytokine production by T cells, antigen-presenting cells, natural killer cells, and natural killer T cells and modulate cytokine receptor signaling. Consistent with their important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of several inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. In contrast, stimulation of OX40 has been shown to be a candidate for therapeutic immunization strategies against cancer and infectious diseases.The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of OX40L Pathway Inhibitor (OX40) pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.