Background: CD47 contains an Ig-like type V (immunoglobulin-like) domain and is a receptor for the C-terminal cell-binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein involved in the increase in intracellular calcium concentration that occurs when a cell attaches to the extracellular matrix. It is widely distributed in adult normal tissues and ovarian tumors, and is particularly abundant in some epithelia and brain. CD47 may play a role in membrane transport and/or integrin-dependent signaling. This can prevent premature removal of red blood cells. It may also be related to changes in membrane permeability after viral infection. CD47, which functions as an adhesion receptor for THBS1 on platelets, plays a role in both cell adhesion and integrin modulation. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of CD47 pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.