Background: CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane unilateral glycoprotein and belongs to the nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate cell attachment and entry of poliovirus (PV), the etiological agent of the central nervous system disease poliomyelitis. Normal cellular function is the formation of intercellular adherens junctions between epithelial cells. CD155 may contribute to an effective humoral immune response generated in the intestinal immune system. DNAM-1 and CD96 have been shown to recognize and bind to CD155, which promotes adhesion, migration and killing of NK cells, thereby effectively inducing cell-mediated tumor-specific immunity..The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of CD155 pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.