Background: The cluster of differentiation system (CD) is often used as cell markers in immunophenotyping. Different cells of the immune system can be recognized by surface CD molecules, which are related to the immune function of the cell. There are more than 320 unique CD clusters and subgroups have been identified. Some CD molecules act as important receptors or ligands for the cell, triggering a signaling cascade that then changes the behavior of the cell. Some CD proteins are not involved in cell signaling but have other functions such as cell adhesion. CD120a (diverse group 120a), also known as TNFR1/TNFRSF1A, is a member of the CD family, a superfamily of tumor necrosis factor receptors. CD120a is one of the most important receptors for tumor necrosis factor-alpha. It has been shown to localize via the death domain (DD) to both plasma membrane lipid rafts and the transgolgi complex. CD120a can activate the transcription factor NF-κB, mediate apoptosis and regulate inflammatory processes..The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of TNFR1 pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.