Background: Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF receptor superfamily. This protein and TNF receptor 1 form a heterocomplex that mediates the accumulation of two anti-apoptotic proteins c-IAP1 and c-IAP2 with E3-ubiquitin ligase activity. Studies in mice also suggest a role for this protein in protecting neurons from apoptosis by stimulating antioxidant pathways. TNFR2/CD120b/TNFRSF1B is not a significant determinant of genetic risk for type 2 diabetes, associated peripheral neuropathy and hypertension, and associated metabolic traits in a North Indian population. Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B functions as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 inhibits TNF-alpha-induced apoptosis, suggesting that it regulates TNF-alpha by antagonizing its biological activity..The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of TNFR2 pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.