Background: TNFRSF11A is a member of the TNF receptor superfamily. In the mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed at high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is a necessary mediator for the development of osteoclasts and lymph nodes. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins through which this receptor induces NF-kappa B and MAPK8/JNK activation. Defects in TNFRSF11A can cause familial expansive osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Deficiencies in TNFRSF11A can also cause Paget’s disease of bone type 2 (PDB2). PDB2 is a bone remodeling disease with clinical similarities to FEO. Defects in TNFRSF11A cause autosomal recessive osteopetrosis type 7, characterized by abnormally dense bone resulting from defective resorption of immature bone.The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of RANK pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.