Background: Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine that was originally characterized for its ability to promote B-cell and dendritic cell (DC) activation. Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, that is important in allergic inflammation. Subsequent studies have shown that TSLP promotes T-helper type 2 (TH2) cell responses, which are involved in immunity against some helminths and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. TSLP can promote TH2 cytokine-mediated inflammation by directly promoting the effector functions of CD4+ TH2 cells, basophils and other granulocyte populations, while limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues.The KRIBIOLISA Inhibitor Assay Kits available enable researchers to test the inhibitory effects of various compounds on specific enzymes at a higher output. These assays can help identify or characterize enzyme inhibitors, which is important in early drug discovery and development. They can also be useful in characterizing enzyme activity. These Inhibitor assay kits contain a known inhibitor as a control.
This Assay kit is designed to facilitate the identification and characterization of TSLP pathway inhibitors.
Assay Features include:
– Ready to use protocol with pre-coated breakapart wells for ease of use
– Standardisation and High Reproducibility
– Lot to Lot Consistency
– Accuracy and Precision
Validated against seven points for a Gold Ring Standard Quality – the benchmark sign for Krishgen quality.
The kits are used for assessing the specific biomarker in samples analyte which may be serum, plasma, biological fluids and cell culture supernatant.
Unlike competitor assays available, we offer pre-coated ready-to-use assays to ensure high level of reproducibility and accuracy.